You are viewing the site in preview mode

Skip to main content

Advertisement

Table 2 Summary of references to published mammalian cell survival data measured in experiments at high LET

From: Theoretical analysis of the dose dependence of the oxygen enhancement ratio and its relevance for clinical applications

Ref. Cells Rad. type LET (keV/μm) α a h a h )1/2 OER(D)
[26] V79 argon 94 1.5 3.4
[45]* V79 carbon 102 2.7 1.1
  V79 neon 110 2.0 1.3
  HSG carbon 88 2.2 1.3
  HSG neon 84 2.9 1.6
[38] R1 α-particles 110   
[39] R1 carbon 95   
[46] R1 carbon 90 2.0 1.6
  R1 carbon 95 1.8 1.7
  R1 neon 90 1.4 1.9
  R1 neon 120 1.7 1.5
  R1 argon 95 2.1 1.3
[41] T1 carbon 85 2.7 1.4
  T1 neon 100 1.8 2.9
  T1 argon 81 2.3 2.4
  T1 argon 91 2.0 2.5
  T1 argon 117 1.7 1.7
[44] U251 8 keV x-rays > 50 1.3 > 2.9
  1. *Because of the large amount of the data in this reference for the LET range between 80 and 120 keV/μm, only a few representative cases are listed here to demonstrate the OER behavior.
  2. For each reference the cell line, the ion beam type, the LET, the ratios of the radiosensitivity parameters (if provided) under aerobic (a) and hypoxic (h) conditions and the OER behavior as a function of dose ( increases, decreases or → remains nearly constant with increasing single dose) are given. The high-LET range was chosen between 80 and 120 keV/μm.