Dose dependence of OER for V79 and T1 cells. Dependence of OER on dose per fraction given to hypoxic cells for V79 (Panels A and B) and T1 cell lines (Panels C and D) at low-LET (Panels A and C) and high-LET (B and D). Solid lines show the model calculations for oxygen partial pressures p
in vivo between 0.01 and 20 mmHg (p
= 30 mmHg). Dashed lines correspond to cell experiments in vitro under extreme hypoxia (p
= 0.01 mmHg, p
= 160 mmHg).