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Table 1 ED50 values for radiation and gossypol in human leukemic cells

From: AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis

  U937 Jurkat T
Radiation (Gy) 21.6 12.6
AT-101 (μM) 2.4 1.9
(±)-Gossypol (μM) 5.8 2.4
  1. Values are derived from full dose-response curves for each stimulus at t = 24 h; data are mean values from 2 independent experiments.