You are viewing the site in preview mode

Skip to main content

Advertisement

Table 5 Impact of patient-related and dose-volume-related factors on symptoms/problems in multivariate analysis

From: Self-assessed bowel toxicity after external beam radiotherapy for prostate cancer - predictive factors on irritative symptoms, incontinence and rectal bleeding

  factor time A time B time C time D
   HR [95%CI]/p-value/incidence with presence vs. absence of factor
painful bowel movements ≥rarely R70≥25% - - - 0.4 [0.2-0.9] p = 0.03 27% vs. 45%
  haemorrhoids 4.5 [1.6-12] p < 0.01 53% vs. 20% 6.3 [1.3-30] p = 0.02 77% vs. 43% 2.7 [1.0-7.4] p = 0.05 59% vs. 34% -
  chronic renal failure - - - 7.2 [1.4-36] p = 0.02 75% vs. 29%
bloody stools ≥rarely PTV≥300 cm3 - - - 8.2 [2.4-28] p < 0.01 17% vs. 4%
  R70≥25% - - - 0.2 [0.1-0.6] p < 0.01 11% vs. 23%
  haemorrhoids - - 3.5 [1.0-12] p < 0.05 24% vs. 8% 4.0 [1.2-13] p = 0.02 29% vs. 12%
  stroke in past history - - - 7.2 [2.0-26] p < 0.01 42% vs. 12%
moderate/big problem from:      
bowel habits overall R70≥25% - 0.4 [0.2-0.9] p = 0.03 26% vs. 52% 0.4 [0.2-1.0] p < 0.05 15% vs. 32% -
  haemorrhoids 8.1 [2.5-26] p < 0.01 29% vs. 5% 3.4 [1.0-11] p < 0.05 62% vs. 28% 5.9 [2.1-17] p < 0.01 53% vs. 15% 3.3 [1.1-10] p = 0.04 29% vs. 12%
  chronic renal failure - - - 7.9 [1.9-33] p < 0.01 50% vs. 12%
rectal urgency R70≥25% - - 0.3 [0.1-0.6] p < 0.01 13% vs. 35% -
  NHT 4.3 [1.5-12] p < 0.01 11% vs. 3% - - -
  haemorrhoids 5.2 [1.5-12] p = 0.03 18% vs. 5% 3.7 [1.2-12] p = 0.03 62% vs. 30% - 3.4 [1.1-10] p = 0.03 29% vs. 12%
  chronic renal failure - - - 4.9 [1.1-22] p = 0.04 28% vs. 12%
losing control of stools age≥70 years - - 3.6 [1.0-12] p < 0.05 11% vs. 3% -
bloody stools haemorrhoids - - - 7.0 [1.2-39] p = 0.03 12% vs. 2%