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Figure 5 | Radiation Oncology

Figure 5

From: The radiosensitizer 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide induces DNA damage in EMT-6 mammary carcinoma cells

Figure 5

ROS generation by DCQ in EMT-6 cells. A. Cells were treated with 10 μM DCQ for 30 min before measuring ROS release by the DCFH-DA assay as described in the materials and methods. B & C. EMT-6 cells were pretreated for 2 h with the strong anti-oxidants Tiron and NAC, then with DCQ (2.5, 5 and 10 μM), and later subjected to 0 Gy (-IR) or 10 Gy (+IR) radiation. Afterwards, cells were replenished with drug-free media and incubated for an additional 20 h before the determination of cell proliferation. The values plotted represent an average (± SD) of two independent experiments. ROS: Reactive oxygen species.

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