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  1. Content type: Methodology

    The purpose of this study is to evaluate the impact of two methods of reporting planned dose distributions on the Gamma analysis pass rates for comparison with measured 2D film dose and simulated delivered 3D ...

    Authors: Yixiu Kang, Jiajian Shen, Wei Liu, Paige A. Taylor, Hunter S. Mehrens, Xiaoning Ding, Yanle Hu, Erik Tryggestad, Sameer R. Keole, Steven E. Schild, William W. Wong, Mirek Fatyga and Martin Bues

    Citation: Radiation Oncology 2019 14:108

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  2. Content type: Research

    Consistent results are lacking as regards the comparative effectiveness of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) versus conventional intensity-modulated radiotherapy in pati...

    Authors: Daquan Wang, Nan Bi, Tao Zhang, Zongmei Zhou, Zefen Xiao, Jun Liang, Dongfu Chen, Zhouguang Hui, Jima Lv, Xiaozhen Wang, Xin Wang, Lei Deng, Wenqing Wang, Jingbo Wang, Chunyu Wang, Xiaotong Lu…

    Citation: Radiation Oncology 2019 14:106

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  3. Content type: Research

    Despite recent advances in multimodal treatments, the prognosis of patients with glioblastoma multiforme (GBM) remains poor. The aim of this study was to evaluate the efficacy of moderately hypofractionated si...

    Authors: Liangzhi Zhong, Lu Chen, Shengqing Lv, Qingrui Li, Guangpeng Chen, Wen Luo, Pu Zhou and Guanghui Li

    Citation: Radiation Oncology 2019 14:104

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  4. Content type: Research

    In this dosimetric study, a dedicated planning tool for single isocenter stereotactic radiosurgery for multiple brain metastases using dynamic conformal arc therapy (DCAT) was compared to standard volumetric m...

    Authors: Jan Hofmaier, Raphael Bodensohn, Sylvia Garny, Indrawati Hadi, Daniel F. Fleischmann, Michael Eder, Yavuz Dinc, Michael Reiner, Stefanie Corradini, Katia Parodi, Claus Belka and Maximilian Niyazi

    Citation: Radiation Oncology 2019 14:103

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  5. Content type: Research

    Radiation treatment to the regional nodes results in an improvement in survival in breast cancer according to a meta-analysis of randomized trials. However, different volumes were targeted in these studies: br...

    Authors: Jan Haussmann, Wilfried Budach, Balint Tamaskovics, Edwin Bölke, Stefanie Corradini, Freddy-Joel Djiepmo-Njanang, Kai Kammers and Christiane Matuschek

    Citation: Radiation Oncology 2019 14:102

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  6. Content type: Research

    The functional outcome after the treatment of laryngeal cancer is tightly related to the quality of life of affected patients. The aim of this study is to describe the long-term morbidity and functional outcom...

    Authors: Lukas Anschuetz, Mohamed Shelan, Marco Dematté, Adrian D. Schubert, Roland Giger and Olgun Elicin

    Citation: Radiation Oncology 2019 14:101

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  7. Content type: Research

    The data regarding a transposed ovary in intensity-modulated radiotherapy (IMRT) are not sufficient. Here we aim to investigate the adequate dose constraint of ovarian transposition before radiotherapy in cerv...

    Authors: Lina Yin, Saiquan Lu, Jun Zhu, Weiling Zhang and Guihao Ke

    Citation: Radiation Oncology 2019 14:100

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  8. Content type: Research

    Determining the appropriate gross tumor volume is important for irradiation planning in addition to palliative radiation for bone metastases. While irradiation planning is commonly performed using simulation c...

    Authors: Yuki Wada, Akira Anbai, Satoshi Kumagai, Eriko Okuyama, Kento Hatakeyama, Noriko Takagi and Manabu Hashimoto

    Citation: Radiation Oncology 2019 14:98

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  9. Content type: Research

    The aim of this study was to assess the correlations between the levels of blood glucose (BG) and the dose of radiation therapy (RT) to the central gustatory system (GS) in glioblastoma multiforme (GBM) patients.

    Authors: Marciana N. Duma, Nadja I. Oszfolk, Tobias Boeckh-Behrens, Markus Oechsner, Claus Zimmer, Bernhard Meyer, Paul T. Pfluger and Stephanie E. Combs

    Citation: Radiation Oncology 2019 14:97

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  10. Content type: Research

    It is uncertain if whole-pelvic irradiation (WPRT) in addition to dose-escalated prostate bed irradiation (PBRT) improves biochemical progression-free survival (bPFS) after prostatectomy for locally advanced t...

    Authors: Carola Link, Patrick Honeck, Akiko Makabe, Frank Anton Giordano, Christian Bolenz, Joerg Schaefer, Markus Bohrer, Frank Lohr, Frederik Wenz and Daniel Buergy

    Citation: Radiation Oncology 2019 14:96

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  11. Content type: Research

    To assess toxicity and quality-of-life (QOL) after carbon ion radiotherapy (CIRT) at the Shanghai Proton and Heavy Ion Center (SPHIC) and identify clinical factors that correlate with urinary, bowel and sexual...

    Authors: Yafang Zhang, Ping Li, Qi Yu, Shuang Wu, Xue Chen, Qing Zhang and Shen Fu

    Citation: Radiation Oncology 2019 14:94

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  12. Content type: Research

    Liver tumors are subject to motion with respiration, which is typically accounted for by increasing the target volume. The prescription dose is often reduced to keep the mean liver dose under a threshold level...

    Authors: M. Gargett, C. Haddad, A. Kneebone, J. T. Booth and N. Hardcastle

    Citation: Radiation Oncology 2019 14:93

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  13. Content type: Review

    Magnetic Resonance-guided radiotherapy (MRgRT) marks the beginning of a new era. MR is a versatile and suitable imaging modality for radiotherapy, as it enables direct visualization of the tumor and the surrou...

    Authors: S. Corradini, F. Alongi, N. Andratschke, C. Belka, L. Boldrini, F. Cellini, J. Debus, M. Guckenberger, J. Hörner-Rieber, F. J. Lagerwaard, R. Mazzola, M. A. Palacios, M. E. P. Philippens, C. P. J. Raaijmakers, C. H. J. Terhaard, V. Valentini…

    Citation: Radiation Oncology 2019 14:92

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  14. Content type: Research

    Although circular collimator arcs (CCA) and dynamic conformal arcs (DCA) are commonly used linear accelerator-based treatment planning techniques for intracranial stereotactic radiosurgery (SRS) of a small sin...

    Authors: Yongsook C. Lee and Yongbok Kim

    Citation: Radiation Oncology 2019 14:91

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  15. Content type: Research

    To evaluate the practicality of NS-21 cream with regard to its skin-related toxicity in patients with head and neck cancer (HNC) who are undergoing concurrent chemoradiation therapy (CCRT) or radiotherapy (RT).

    Authors: Hsiu-Ling Chou, Pei-Wei Shueng, Li-Jen Liao, Chen-Xiong Hsu, Deng-Yu Kuo, Wu-Chia Lo, Pei-Yu Hou, Li-Ying Wang, San-Fang Chou and Chen-Hsi Hsieh

    Citation: Radiation Oncology 2019 14:90

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  16. Content type: Research

    Glioblastoma (GB) is the most common primary malignant brain tumor. Standard medical treatment consists of a maximal safe surgical resection, subsequently radiation therapy (RT) and chemotherapy with temozolom...

    Authors: Jeroen Verhoeven, Julie Bolcaen, Valerie De Meulenaere, Ken Kersemans, Benedicte Descamps, Sam Donche, Caroline Van den Broecke, Tom Boterberg, Jean-Pierre Kalala, Karel Deblaere, Christian Vanhove, Filip De Vos and Ingeborg Goethals

    Citation: Radiation Oncology 2019 14:89

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  17. Content type: Research

    Standard radiobiology theory of radiation response assumes a uniform innate radiosensitivity of tumors. However, experimental data show that there is significant intratumoral heterogeneity of radiosensitivity....

    Authors: J. C. L. Alfonso and L. Berk

    Citation: Radiation Oncology 2019 14:88

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  18. Content type: Research

    This study set out to evaluate the effect of dose rate on normal tissues (the lung, in particular) and the variation in the treatment efficiency as determined by the monitor unit (MU) and energy applied in Lin...

    Authors: Jaeman Son, Noorie Choi, Jung-in Kim, Jong Min Park, Hong-Gyun Wu, Hyun-Cheol Kang and Chang Heon Choi

    Citation: Radiation Oncology 2019 14:87

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  19. Content type: Research

    To investigate the potential impact of fractionation regimes and overall treatment time (OTT) on lymphopenia during definitive radiotherapy (RT) and its associations with patient outcomes in non-small cell lun...

    Authors: Qianqian Zhao, Gang Chen, Luxi Ye, Shiming Shi, Shisuo Du, Zhaochong Zeng and Jian He

    Citation: Radiation Oncology 2019 14:86

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  20. Content type: Research

    The prognostic significance of radiation dose to the lung or heart is unknown in esophageal cancer patients receiving neoadjuvant chemoradiotherapy followed by surgery (trimodal therapy). This study aimed to d...

    Authors: Jhen-Bin Lin, Li-Chung Hung, Ching-Yuan Cheng, Yu-An Chien, Chou-Hsien Lee, Chia-Chun Huang, Tsai-Wei Chou, Ming-Huei Ko, Yuan-Chun Lai, Mu-Tai Liu, Tung-Hao Chang, Jie Lee and Yu-Jen Chen

    Citation: Radiation Oncology 2019 14:85

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  21. Content type: Review

    Radiation or radiochemotherapy is a common adjuvant therapy for gastric cancer. Intensity-modulated radiation therapy (IMRT) has been demonstrated to provide better dose conformity, allowing dose escalation an...

    Authors: Fang Ren, Shaodan Li, Yin Zhang, Zhifei Zhao, Haiming Wang, Yixin Cui and Maoyun Wang

    Citation: Radiation Oncology 2019 14:84

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  22. Content type: Research

    Low-level laser therapy (LLLT) also called Photobiomodulation therapy (PBMT) could reduce oral mucositis (OM) incidence and severity in head and neck cancer patients treated by chemoradiotherapy, however rando...

    Authors: Florence Legouté, René-Jean Bensadoun, Valérie Seegers, Yoann Pointreau, Delphine Caron, Philippe Lang, Alain Prévost, Laurent Martin, Ulrike Schick, Benjamin Morvant, Olivier Capitain, Gilles Calais and Eric Jadaud

    Citation: Radiation Oncology 2019 14:83

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  23. Content type: Research

    The clinical efficacy of definitive pelvic radiotherapy for primary tumors in patients with newly diagnosed organ metastatic cervical cancer is unclear. Therefore, we conducted a retrospective study to evaluat...

    Authors: Zhuomin Yin, Hanmei Lou, Huarong Tang, Juan Ni, Qiong Zhou and Ming Chen

    Citation: Radiation Oncology 2019 14:82

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  24. Content type: Research

    Intrafraction motion is particularly problematic in case of small target volumes and narrow margins. Here we simulate the dose coverage of intraprostatic lesions (IPL) by simultaneous integrated boosts (SIB). ...

    Authors: Hendrik Ballhausen, Minglun Li, Michael Reiner and Claus Belka

    Citation: Radiation Oncology 2019 14:81

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  25. Content type: Research

    For radiotherapy of abdominal cancer, four-dimensional magnetic resonance imaging (4DMRI) is desirable for tumor definition and the assessment of tumor and organ motion. However, irregular breathing gives rise...

    Authors: Z. van Kesteren, A. van der Horst, O. J. Gurney-Champion, I. Bones, D. Tekelenburg, T. Alderliesten, G. van Tienhoven, R. Klaassen, H. W. M. van Laarhoven and A. Bel

    Citation: Radiation Oncology 2019 14:80

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  26. Content type: Research

    To reduce radiation doses to the tongue, a patient-specific semi-customized tongue displacement device (SCTDD) was developed using a 3D printer (3DP) for head and neck (H&N) radiation therapy (RT). Dosimetric ...

    Authors: Chae-Seon Hong, Dongryul Oh, Sang Gyu Ju, Yong Chan Ahn, Cho Hee Na, Dong Yeol Kwon and Cheol Chong Kim

    Citation: Radiation Oncology 2019 14:79

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  27. Content type: Research

    Breast cancer is the most common invasive tumor in women worldwide and the second cause of cancer-related deaths. After breast conserving surgery the tumor bed gets irradiated. Radiation-induced tumor cell dea...

    Authors: Anna Rothammer, Eva K. Sage, Caroline Werner, Stephanie E. Combs and Gabriele Multhoff

    Citation: Radiation Oncology 2019 14:78

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  28. Content type: Methodology

    Commissioning of treatment planning systems (TPS) and beam delivery for scanned light ion beams is an important quality assurance task. This requires measurement of large sets of high quality dosimetric data i...

    Authors: O. Jäkel, B. Ackermann, S. Ecker, M. Ellerbrock, P. Heeg, K. Henkner and M. Winter

    Citation: Radiation Oncology 2019 14:77

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  29. Content type: Research

    The radiation transmission through the multileaf collimators is undesired in modern techniques such as volumetric modulated arc therapy (VMAT). According to identical plans, in this study, we aim to investigat...

    Authors: Kai Xie, Hongfei Sun, Liugang Gao, Tao Lin, Jianfeng Sui and Xinye Ni

    Citation: Radiation Oncology 2019 14:75

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  30. Content type: Research

    The impact of sex on prognosis of patients with esophageal squamous cell cancer (ESCC) who underwent definitive radiotherapy remained unclear. The present study aimed to determine the impact of sex on the prog...

    Authors: He-San Luo, Hong-Yao Xu, Ze-Sen Du, Xu-Yuan Li, Sheng-Xi Wu, He-Cheng Huang and Lian-Xing Lin

    Citation: Radiation Oncology 2019 14:74

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  31. Content type: Research

    To evaluate the effect of timing of radiotherapy (RT) on survival in patients with newly diagnosed primary glioblastoma (GBM) treated with the same therapeutical protocol.

    Authors: Sotirios Katsigiannis, Boris Krischek, Stefanie Barleanu, Stefan Grau, Norbert Galldiks, Marco Timmer, Christoph Kabbasch, Roland Goldbrunner and Pantelis Stavrinou

    Citation: Radiation Oncology 2019 14:73

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  32. Content type: Research

    An objective way to qualify the effect of radiotherapy (RT) on lung tissue is the analysis of CT scans after RT. In this analysis we focused on the changes in Hounsfield units (ΔHU) and the correlation with th...

    Authors: Christina Schröder, Rita Engenhart-Cabillic, Sven Kirschner, Eyck Blank and André Buchali

    Citation: Radiation Oncology 2019 14:72

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  33. Content type: Review

    Different studies have proved in recent years that hypofractionated radiotherapy (RT) improves overall survival of patients affected by locally advanced, unresectable, pancreatic cancer.

    Authors: Luca Boldrini, Davide Cusumano, Francesco Cellini, Luigi Azario, Gian Carlo Mattiucci and Vincenzo Valentini

    Citation: Radiation Oncology 2019 14:71

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  34. Content type: Research

    In this study, an external 8 mm thick aluminum target was installed on the upper accessory tray mount of a medical linear accelerator head. The purpose of this study was to determine the effects of the externa...

    Authors: Jonggeun Baek, Hyungdong Kim, Byungyong Kim, Youngkee Oh and Hyunsoo Jang

    Citation: Radiation Oncology 2019 14:70

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  35. Content type: Research

    Intraductal carcinoma of the prostate (IDC-P) is an independent biomarker of recurrence and survival with particular treatment response, yet no study has tested its response to radiotherapy. The aim of our pro...

    Authors: Vincent Q. Trinh, Nazim Benzerdjeb, Ségolène Chagnon-Monarque, Nicolas Dionne, Guila Delouya, André Kougioumoutzakis, Jennifer Sirois, Roula Albadine, Mathieu Latour, Anne-Marie Mes-Masson, Hélène Hovington, Alain Bergeron, Kevin C. Zorn, Yves Fradet, Fred Saad, Daniel Taussky…

    Citation: Radiation Oncology 2019 14:60

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  36. Content type: Research

    The aim was to evaluate the outcome, especially locoregional control of patients with locally advanced salivary gland carcinoma (SGC) with perineural spread (Pn1) and/or positive resection margins (R1/2) after...

    Authors: Marlen Haderlein, Claudia Scherl, Sabine Semrau, Sebastian Lettmaier, Markus Hecht, Florian Putz, Heinrich Iro, Abbas Agaimy and Rainer Fietkau

    Citation: Radiation Oncology 2019 14:68

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  37. Content type: Research

    Multimodal treatment with neoadjuvant chemoradiation followed by surgery (nCRT + S) is the treatment of choice for patients with locally advanced or node-positive esophageal squamous cell carcinoma (E-SCC). Th...

    Authors: Stefan Münch, Steffi U. Pigorsch, Michal Devečka, Hendrik Dapper, Marcus Feith, Helmut Friess, Wilko Weichert, Moritz Jesinghaus, Rickmer Braren, Stephanie E. Combs and Daniel Habermehl

    Citation: Radiation Oncology 2019 14:66

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  38. Content type: Research

    The differential diagnosis between radiation necrosis, tumor recurrence and tumor progression is crucial for the evaluation of treatment response and treatment planning.

    Authors: Rosa Morabito, Concetta Alafaci, Stefano Pergolizzi, Antonio Pontoriero, Giuseppe Iati’, Lilla Bonanno, Michele Gaeta, Francesco Maria Salpietro, Enricomaria Mormina, Marcello Longo and Francesca Granata

    Citation: Radiation Oncology 2019 14:65

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  39. Content type: Research

    Radiotherapy plays an important role in the multimodal treatment of breast cancer. The response of a breast tumour to radiation depends not only on its innate radiosensitivity but also on tumour repopulation b...

    Authors: Mark Gray, Arran K. Turnbull, Carol Ward, James Meehan, Carlos Martínez-Pérez, Maria Bonello, Lisa Y. Pang, Simon P. Langdon, Ian H. Kunkler, Alan Murray and David Argyle

    Citation: Radiation Oncology 2019 14:64

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  40. Content type: Research

    Patients with plasma-cell neoplasia usually suffer from systemic disease, although a minority (< 5%) may present with solitary involvement of bone or soft tissue (extramedullary plasmacytoma (EMP)). Radiothera...

    Authors: Michael Oertel, Khaled Elsayad, Kai Jannes Kroeger, Uwe Haverkamp, Claudia Rudack, Georg Lenz and Hans Theodor Eich

    Citation: Radiation Oncology 2019 14:63

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  41. Content type: Research

    To perform quality assurance of non-coplanar, volumetric-modulated arc therapy featuring continuous couch rotation (CCR-VMAT) using a C-arm linear accelerator.

    Authors: Hideaki Hirashima, Mitsuhiro Nakamura, Yuki Miyabe, Nobutaka Mukumoto, Tomohiro Ono, Hiraku Iramina and Takashi Mizowaki

    Citation: Radiation Oncology 2019 14:62

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  42. Content type: Research

    This study investigated the impact of post-radiation sinusitis on the prognosis of nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT).

    Authors: Chih-Jen Huang, Ming-Yii Huang, Ming-Chen Paul Shih, Kai-yuan Cheng, Ka-Wo Lee, Tzu-Ying Lu, Shyng-Shiou Yuan and Pen-Tzu Fang

    Citation: Radiation Oncology 2019 14:61

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