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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Content type: Research

    Brachytherapy (BT) is a vital component of the curative treatment of locally advanced cervical cancer. The American Brachytherapy Society has published guidelines for high dose rate (HDR) BT with recommended d...

    Authors: Kara D. Romano, Colin Hill, Daniel M. Trifiletti, M. Sean Peach, Bethany J. Horton, Neil Shah, Dylan Campbell, Bruce Libby and Timothy N. Showalter

    Citation: Radiation Oncology 2018 13:129

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  2. Content type: Research

    Intra-fraction motion represents a crucial issue in the era of precise radiotherapy in several settings, including breast irradiation. To date, only few data exist on real-time measured intra-fraction motion i...

    Authors: D. Reitz, G. Carl, S. Schönecker, M. Pazos, P. Freislederer, M. Niyazi, U. Ganswindt, F. Alongi, M. Reiner, C. Belka and S. Corradini

    Citation: Radiation Oncology 2018 13:128

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  3. Content type: Research

    Combined stereotactic body radiotherapy (SBRT) for lung lesions and conventional radiotherapy (CRT) for nodal areas may be more effective than CRT alone in patients with locally advanced lung cancer.

    Authors: Yeon Joo Kim, Su Ssan Kim, Si Yeol Song and Eun Kyung Choi

    Citation: Radiation Oncology 2018 13:127

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  4. Content type: Research

    Heart-sparing techniques are time and resource intensive, although not all patients require the use of these strategies. This study evaluates the performance of different distance metrics in predicting the nee...

    Authors: Lucas C. Mendez, Alexander V. Louie, Carolina Moreno, Matt Wronski, Andrew Warner, Eric Leung, Roberto Sakuraba, Juliana K. Helito, Ana Rezende, Icaro T. Carvalho and Eduardo Weltman

    Citation: Radiation Oncology 2018 13:124

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  5. Content type: Research

    Postoperative (chemo) radiation improves tumor control and survival in high-risk patients with head and neck squamous cell carcinoma based on established risk factors. The clinical cooperation group “Personali...

    Authors: Cornelius Maihoefer, Lars Schüttrumpf, Corinna Macht, Ulrike Pflugradt, Julia Hess, Ludmila Schneider, Christine Woischke, Axel Walch, Philipp Baumeister, Thomas Kirchner, Horst Zitzelsberger, Claus Belka and Ute Ganswindt

    Citation: Radiation Oncology 2018 13:123

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  6. Content type: Research

    The benefits of proton therapy in the treatment of patients with Hodgkin lymphoma (HL) are controversially discussed. Therefore we compared intensitiy modulated proton therapy (IMPT) with intensity modulated r...

    Authors: Christian Baues, Simone Marnitz, Andreas Engert, Wolfgang Baus, Karolina Jablonska, Antonella Fogliata, Andrés Vásquez-Torres, Marta Scorsetti and Luca Cozzi

    Citation: Radiation Oncology 2018 13:122

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  7. Content type: Research

    Carbon-ion radiotherapy (C-ion RT) provides better dose distribution in cancer treatment compared to photons. Additionally, carbon-ion beams provide a higher biological effectiveness, and thus a higher tumor c...

    Authors: Noriyuki Okonogi, Mai Fukahori, Masaru Wakatsuki, Yu Ohkubo, Shingo Kato, Yuhei Miyasaka, Hiroshi Tsuji, Takashi Nakano and Tadashi Kamada

    Citation: Radiation Oncology 2018 13:119

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  8. Content type: Research

    The purpose was to retrospectively evaluate the effect of intensity-modulated radiotherapy (IMRT) on gastrointestinal (GI) toxicities and outcomes compared to three-dimensional conformal radiotherapy (3DCRT) f...

    Authors: Yoko Goto, Akira Nakamura, Ryo Ashida, Katsuyuki Sakanaka, Satoshi Itasaka, Keiko Shibuya, Shigemi Matsumoto, Masashi Kanai, Hiroyoshi Isoda, Toshihiko Masui, Yuzo Kodama, Kyoichi Takaori, Masahiro Hiraoka and Takashi Mizowaki

    Citation: Radiation Oncology 2018 13:118

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  9. Content type: Research

    Deep inspiration breath hold (DIBH) can be performed using different breathing maneuvers, such as DIBH with a thoracic breathing maneuver (T-DIBH) and DIBH with an abdominal breathing maneuver (A-DIBH). Dosime...

    Authors: Feng Zhao, Jiayan Shen, Zhongjie Lu, Yongbiao Luo, Guorong Yao, Luyi Bu, Jia Ge, Xin Yang, Lihua Ning and Senxiang Yan

    Citation: Radiation Oncology 2018 13:116

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  10. Content type: Case report

    Granular cell or Abrikossoff’s tumors are usually benign however rare malignant forms concern 1 to 3% of cases reported. Pelvic locations are exceptional.

    Authors: C. Marchand Crety, C. Garbar, G. Madelis, F. Guillemin, P. Soibinet Oudot, J. C. Eymard and S. Servagi Vernat

    Citation: Radiation Oncology 2018 13:115

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  11. Content type: Research

    The goal of this study is to evaluate the status and future perspectives of clinical trials on positron emission tomography in prostate cancer for diagnostic or therapeutic as well as for surveillance purposes.

    Authors: Nikola Cihoric, Eugenia Vlaskou Badra, Alexandros Tsikkinis, Vikas Prasad, Stephanie Kroeze, Ivan Igrutinovic, Branislav Jeremic, Marcus Beck, Sebastian Zschaeck, Peter Wust and Pirus Ghadjar

    Citation: Radiation Oncology 2018 13:113

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  12. Content type: Research

    In intensity modulated radiation therapy (IMRT) quality assurance (QA), evaluation of QA result using a pass/non-pass strategy under an acceptance criterion often suffers from lack of information on how good t...

    Authors: Dong-Su Kim, Siyong Kim, Seong-Hee Kang, Tae-Ho Kim, So-Hyun Park, Kyeong-Hyeon Kim, Min-Seok Cho, Dong-Seok Shin, Yu-Yun Noh, Jin-Beom Chung and Tae Suk Suh

    Citation: Radiation Oncology 2018 13:112

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  13. Content type: Research

    We investigated the effectiveness of one education course to lower the severity of anxiety and depression symptoms among breast cancer (BC) patients during radiotherapy (RT).

    Authors: Zhensheng Li, Wenhui Geng, Junpu Yin and Jun Zhang

    Citation: Radiation Oncology 2018 13:111

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  14. Content type: Research

    The aim of the present study was to evaluate the influence of the applied safety margins of modern intensity-modulated radiotherapy (IMRT) in patients with high-grade meningiomas on local control and recurrenc...

    Authors: Barbara Zollner, Ute Ganswindt, Cornelius Maihöfer, Stefanie Corradini, Nathalie Lisa Albert, Christian Schichor, Claus Belka and Maximilian Niyazi

    Citation: Radiation Oncology 2018 13:110

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  15. Content type: Research

    The purpose of this study was to evaluate the impact of markerless on-board kilovoltage (kV) cone-beam computed tomography (CBCT)-based positioning uncertainty on determination of the planning target volume (P...

    Authors: Katsumi Hirose, Mariko Sato, Yoshiomi Hatayama, Hideo Kawaguchi, Fumio Komai, Makoto Sohma, Hideki Obara, Masashi Suzuki, Mitsuki Tanaka, Ichitaro Fujioka, Koji Ichise, Yoshihiro Takai and Masahiko Aoki

    Citation: Radiation Oncology 2018 13:106

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  16. Content type: Research

    The use of intraprostatic gold fiducial markers (FMs) ensures highly accurate and precise image-guided radiation therapy for patients diagnosed with prostate cancer thanks to the ease of localising FMs on phot...

    Authors: Matteo Maspero, Peter R. Seevinck, Nicole J. W. Willems, Gonda G. Sikkes, Geja J. de Kogel, Hans C. J. de Boer, Jochem R. N. van der Voort van Zyp and Cornelis A. T. van den Berg

    Citation: Radiation Oncology 2018 13:105

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  17. Content type: Research

    While breast radiotherapy typically includes regional nodal basins, the treatment of the internal mammary nodes (IMN) has been controversial due to concern for long-term cardiac toxicity. For high risk patient...

    Authors: Macklin H. Nguyen, Myra Lavilla, Janice N. Kim and L. Christine Fang

    Citation: Radiation Oncology 2018 13:103

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  18. Content type: Case report

    The existence of abscopal effects has been suggested already a long time ago, but only recently with the advent of immune checkpoint inhibition in clinical oncology and modern imaging techniques has it become ...

    Authors: Christian Britschgi, Oliver Riesterer, Irene A. Burger, Matthias Guckenberger and Alessandra Curioni-Fontecedro

    Citation: Radiation Oncology 2018 13:102

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