Hypofractionated stereotactic radiation therapy for recurrent glioblastoma: single institutional experience
© Ciammella et al.; licensee BioMed Central Ltd. 2013
Received: 9 July 2013
Accepted: 17 September 2013
Published: 25 September 2013
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Tumor control and survival have improved with the use of radiotherapy (RT) plus concomitant and adjuvant chemotherapy, but the prognosis remain poor. In most cases the recurrence occurs within 7–9 months after primary treatment. Currently, many approaches are available for the salvage treatment of patients with recurrent GBM, including resection, re-irradiation or systemic agents, but no standard of care exists.
We analysed a cohort of patients with recurrent GBM treated with frame-less hypofractionated stereotactic radiation therapy with a total dose of 25 Gy in 5 fractions.
Of 91 consecutive patients with newly diagnosed GBM treated between 2007 and 2012 with conventional adjuvant chemo-radiation therapy, 15 underwent salvage RT at recurrence. The median time interval between primary RT and salvage RT was 10.8 months (range, 6–54 months). Overall, patients undergoing salvage RT showed a longer survival, with a median survival of 33 vs. 9.9 months (p= 0.00149). Median overall survival (OS) from salvage RT was 9.5 months. No patients demonstrated clinically significant acute morbidity, and all patients were able to complete the prescribed radiation therapy without interruption.
Our results suggest that hypofractionated stereotactic radiation therapy is effective and safe in recurrent GBM. However, until prospective randomized trials will confirm these results, the decision for salvage treatment should remain individual and based on a multidisciplinary evaluation of each patient.
KeywordsRecurrent glioblastoma Stereotactic radiation therapy Re-irradiation Acute toxicity
The current standard of care for glioblastoma (GBM) is concurrent Temozolomide (TMZ) and conventional radiotherapy followed by 6 maintenance cycles of adjuvant TMZ. Despite standard of care therapy, recurrence rates remain high (>90%) with a median overall survival (OS) of 15–18 months .
In recent years a lot of mono-therapy or combination chemotherapeutic strategies have been evaluated in patients with recurrent or progressive GBM. The alkylant agents (nitrosoureas, procarbazine), used in the past as first-line treatment, are used today as second-line therapy for recurrence or progression. Overall, the 6-months progression-free survival (PFS) and median OS with second-line therapy with alkylant agents ranged from 13 to 24% and from 5 to 11 months, respectively [2–8]. Numerous trials have evaluated the efficacy and safety of TMZ as a monotherapy for recurrent GBM in patients previously treated with chemotherapy, mostly nitrosurea-based [9–15]. Some recent studies evaluated in TMZ-pretreated patients a second-line TMZ based therapy [16–21]. In one of these studies, the TMZ resulted more efficacious than procarbazine (PFS at 6 months= 21% vs 8%) . Six recent trials of TMZ-pretreated patients evaluated TMZ re-challenge [17–21]. Unfortunately, considering the small numbers of patients included in these studies and the wide range of TMZ regimen tested, there was no evidence that one regimen was advantageous over another, and despite some improvements in PFS none of them was associated with a better survival. The repeated surgery is feasible only in few cases of recurrent GBM and is not recommended for patients with involvement of pre-specified eloquent/critical brain regions . The data related to reoperation have been derived from retrospective studies, but it is known that positive prognostic factors of reoperation for recurrent GBM are a younger age (≤70 years), a smaller tumor volume (≤50 cm3) and pre-operative KPS greater than 80% [22, 23].
Today, for recurrent GBM the re-irradiation remains a palliative option for a selected group of patients, i.e. those with a KPS greater than 60%, a tumor size of up to 40 mm, and a time to progression from the surgery of at least 6 months . Usually, a stereotactic radiotherapy technique is applied , but the fractionation schedule and the prescribed total dose are various and no randomized trials are available. Both single-fraction stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT) have been reported to have minimal toxicity, with median survivals of 6–10 months after SRS [26–30] or FSRT [31–33]. Recently, some studies also have evaluated the safety and efficacy of the combination of fractionated RT and concurrent chemotherapy in recurrent high-grade gliomas showing a median OS and PFS from re-irradiation of 8–13 and 5–8 months, respectively [34–37].
Our retrospective analysis focused on the efficacy and toxicity of a hypofractionated stereotactic radiotherapy for recurrent GBM in a cohort of patients previously treated with standard therapy.
Methods and materials
This is a retrospective study of efficacy and safety of hypofractionated stereotactic radiation therapy (SRT) delivered at 5 fractions of 5 Gy each for management of recurrent intracranial GBM. All patients previously underwent a conventional adjuvant chemo-radiation therapy according to Stupp protocol after a maximal surgical resection for a newly diagnosed GBM. The histopathological diagnosis of primary GBM was established according to the current World Health Organization Criteria .
The protocol was approved by the local Ethics committee and informed consent was obtained for all patients.
The diagnosis of tumor recurrence was based on the joint opinion of the neuro-radiologist, neurosurgeon, radiation oncologist and neuro-oncologist, and was defined as appearance of new contrast-enhanced lesion(s) on T1-weichted MRI or an increase of 25% or more of the volume of the initial enhanced lesion(s). In case of doubt between tumor recurrence and pseudo-progression a MR imaging was repeated after one month. Recurrences were defined, as suggested by Lee et at , as " in-field" if > 80% of the tumour recurrence resided within the prescription 95% isodose surface, and "marginal" if 20% to 80% of the lesion was inside the 95% isodose surface. In all other cases, recurrences were defined as outside of the radiation field. At the time of recurrence, all patients were evaluated for salvage treatment, which included re-resection of the tumor, hypo-fractionated radiation therapy, chemotherapy, or combined approaches.
The indication for re-irradiation at tumor recurrence was evaluated by the interdisciplinary neuro-oncology team and based on: the patient clinical condition (i.e. KPS> 60), the lesion location and the spread of disease (patients with multifocal spread of disease were excluded). All patients undergoing re-irradiation were immobilized in customized thermoplastic shells for CT and MR simulation. The GTV was delineated on the basis of the contrast-enhancing tumor on T1-weighted MRI registered with CT images. For the image registration an automatic fusion algorithm was used; anyway the resulted registration was subsequently checked by mean of anatomic markers and, if needed, manually adjusted. The PTV was generated by applying to GTV an isotropic expansion of 3–5 mm. The critical structures and previously high dose irradiated volumes were contoured. All patients were treated with hypo-fractionated stereotactic radiation therapy with multiple no-coplanar beams using on a standard 6-MV linear accelerator (LINAC). A total dose of 25 Gy prescribed to the 70% isodose line and delivered in 5 consecutive fractions was delivered. A daily pre-treatment verification with orthogonal fields was performed.
All patients were evaluated at four weeks, 12 weeks and once every 3 months after the salvage treatment. The work-up included history and physical examination (with particular regard to KPS, neurological status and toxicity assessment), blood tests and contrast-enhanced brain MRI. No specific quality-of-life questionnaire was administered. Haematologic and no-haematological toxicities were graded according to Common Terminology Criteria for Adverse Events. Other investigations were not performed unless were clinically indicated.
Statistical analysis were performed using the R statistical software (http://www.R-project.org), particularly the survival package. Patient characteristics were compared with Fisher-test and a twosided significance level was chosen at 0.05. Survival curves were estimated using the Kaplan-Meier method. The p-values estimated are those for a two tailed test and the significance level was chosen to be 5%. Cox regression analysis was used for univariate analysis and parameters were tested for proportionally and categorical covariates compared by log-rank test. A multivariate Cox proportional hazards analysis was used to evaluate prognostic factors and treatment with respect to the overall survival from initial diagnosis and from time of recurrence. Variables included in the model were selected when statistically significant in univariate analysis. Data are presented as 1-mont actuarial hazard ratios (HR) with 95% confidence intervals, unless otherwise mentioned.
Between 2007 and 2012 we treated with standard chemo-radiation therapy according to Stupp protocol 91 patients with newly diagnosed GBM. With mean follow-up of 13.9 months (range 1–63 months), the median OS was 15 months, with a PFS of 9 months. In this populations of patients, the age (≤65 years), extent of resection, KPS, RPA class and O6-methylguanine-DNA-methyltransferase (MGMT) methylation were significantly associated with OS.
The pattern of recurrences was analysed in 83 patients who had recurrences. Recurrence occurred "in-field" in 61 patients (73%), at RT field margin in 7 patients (9%) and "out-field" in 15 patients (18%). No patients had CSF/spinal or distant disease recurrence. No correlation between extent of surgery and site of relapse was seen (>0.05). Progression-free survival did not differ significantly between patients with regional or marginal progression and patients with distant recurrences. Comparison of the investigated clinical factors did not differ significantly between the two groups ("in-field" vs "out-field"). No correlation between tumor location, tumor side, extent of primary surgery and pattern of recurrence was found.
Comparison of clinical factors and outcome variables in patients with recurrent glioblastoma treated with different approaches
Best supportive care
RT vs no-RT 0.002
Gender, N0. (%)
Primary Surgery, N0. (%)
Karnofsky performance status at diagnosis (%)
RPA classification at diagnosis, N0. (%)
MGMT Methylation, N0. (%)
Primary Tumor location, N0 (%)
Primary Tumor side, N0 (%)
Type of recurrence, N0 (%)
Karnofsky performance status at recurrence (%)
Median OS from primary diagnosis (months)
RT vs no-RT 0.001
Cox regression analysis OR coef f-p
Time between primary therapy and salvage treatment
Median OS from recurrence(months)
RT vs no-RT 0.001
Cox regression analysisOR coef f-p
The clinical characteristics of the patients in the four treatment groups were similar, except for the median age that was significantly lower in the RT group (p<0.05). The patients who underwent re-irradiation and re-surgery showed better clinical conditions (KPS) compared with patients treated with second-line chemotherapy or untreated (best supportive care), but the difference did not reach statistical significance.
In all re-treated patients, the multivariate Cox proportional hazard analysis confirmed the negative prognostic effect of the older age [hazard ratio (HR): 4.1 (95%CI: 1.5 -10.3), p=0.005] and the biopsy alone [HR: 4.5 (95%CI: 1.4–14.4), p= 0.011] on the OS. No correlation was found between the other analysed factors (sex, MGMT methylation, RPA class, primary tumor side, primary tumor volume, KPS at diagnosis and KPS at recurrence) and OS. In all recurrent patients there was no correlation between OS from recurrence and type of recurrence ("in-field" or "out -field"), though in the group of re-irradiated patients with "in-field" progression had a mild tendency to better OS comparing with patients with "out-field". Surprisingly, in the re-irradiated group, the age alone (with cut-off of 60 years) showed a correlation with OS [HR: 11.92 (95%CI: 1.1-135), p=0.0045]. None of the others assessed factors reached statistical significance.
This retrospective study reports the results of a series of patients affected by GBM treated with conventional chemo-radiation therapy ad diagnosis and who underwent various salvage treatment for their tumor recurrence. The principal focus of our analysis is to evaluate the feasibility and safety of re-irradiation at tumor progression in patients previously irradiated. It is well known that the tumor control and survival in patients with GBM have been improved by the use of radiotherapy plus concomitant and adjuvant TMZ. Unfortunately, the prognosis remain poor with very few long-term survivors. In most cases the recurrence occurs within 7–9 months from initial diagnosis [40–42]. Up to 90% of all GBMs relapse in close proximity to the resection cavity or to the target volume of postoperative radiotherapy [43, 44]. Currently, many approaches are available for the salvage treatment of patients with recurrent GBM after initial chemo-radiation therapy, including resection, re-irradiation or systemic agents, but no standard of care exists. Chemotherapy is the most common treatment option for recurrent GBM, but it is associated, when administered alone, with poor OS ( 4–6 months) .
The drugs commonly used in the treatment of these patients are many (TMZ, carboplatin, procarbazine, bevacizumab and imatinib) administered as single-agent or in combination. Recent series reported promising results with TMZ alone with a 6 months PFS of 30% . The use of Bevacizumab was approved by the US Food and Drug Administration because of some phase II trials indicating prolonged 6-month PFS and OS . Several studies suggest that a more aggressive approach with gross total resection and/or high dose re-irradiation may result in improvement of local control of recurrent GBM. A recent review reported an OS of 3–11 months in patients with recurrent GBM treated with surgery . Young et al.  reported in 24 patients with tumor recurrence treated with surgery alone an OS of 3.3 months. With a combination of re-intervention and chemotherapy, an increase of PFS and OS was reported .
During the last decade, there has been an increased interest in fractionated stereotactic radiation therapy as a palliative treatment of recurrent GBM.
Survey of clinical outcomes after re-irradiation: fractionated stereotactic radiation therapy (FSRT), radiosurgery (SRS), brachytherapy (BT) of recurrent GBM
Type of RT
Outcomes from the re-irradiation
Cho et al.
Median dose of 37.5 Gy (range, 20-45 Gy) /2.5 Gy fractions (range, 1.8-3 Gy)
Median survival 12 months
Cho et al.
Median total dose of 17 Gy delivered to the median of 50% isodose surface
Median survival 11 months
Combs et al.
36 Gy/2 Gy fractions
Median OS 8 months
1-year survival rates 23%
Median PFS 5 months
1-year PFS 5%
Vordermark et al.
Median total dose 30 Gy (range, 20–30 Gy) /5 Gy fractions (range, 4–10 Gy)
Median OS 7.9 months
Simon et al.
Median OS 12.5 months
Chan et al.
Median OS 9.1 months
Larson et al.
15 Gy/1 fraction
Median OS 9.5 months
Combs et al.
15 Gy/1 fraction
Median OS 10 months
Shrieve et al.
13 Gy/1 fraction
Median OS 10.2 months
Shrieve et al.
Median OS 11.5 months
Grosu et al.
Median OS 8 months (for astrocytomas and gliomas)
Kohshi et al.
Median OS 11 months
Ernst-Stecken et al.
35 Gy/7 Gy fractions
6 months PFS 75%
12 months PFS 53%
Fokas et al.
Median dose 30 Gy (range 20-60 Gy)/ 3 Gy fractions (range 2-5 Gy)
Median OS 9 months
1-year PFS 22%
2-year PFS 5%
Henke et al.
31 (2 grade III, 29 grade IV)
Median total dose 20Gy (range, 20–25)/ 5 Gy fractions
Median OS 10.2 months,
Fogh et al.
147 (42 grade III, 105 grade IV)
Median dose 35 Gy in 3.5-Gy fractions
Median OS 11 months for grade III and 8 months for grade IV
Shepherd et al.
Median dose 35 Gy (range, 20–50 Gy)/ 5 Gy fractions
Median OS 10.7 months
Glass et al.
20 (7 grade III, 13 grade IV)
Median dose 38 Gy (range, 35–42 Gy)/ 3.5–6 Gy fractions
Median OS 12.7 months
Hudes et al. 
Median dose 30 Gy (range, 24–35 Gy)/ 3–3.5 Gy fractions
Median OS 10.5 months
Lederman et al.
Total dose 18–36/ 4–9 Gy (weekly)
Median OS 7 months
Voynov et al.
10 (5 WHO grade III, 5 grade IV)
30 Gy /5 Gy fractions
Median OS 10.1 months
A recent review has analysed data from more than 300 GBM patients and has demonstrated that re-irradiation yields an increase of the 6-month PFS, that moves from 28% to 39% and 1-year overall survival of 18% to 48%, without additional chemotherapy . A clinical improvement was observed in 24% to 45% of the cases with patients with KPS <70 apparently having lesser benefit from re-irradiation. Recently particular attention received the combination of stereotactic radiation therapy and TMZ in recurrent GBM. The use of TMZ in addition to radiotherapy was based on the observation that concurrent chemotherapy can potentiate the cytotoxicity of radiation. In a series of 25 patients with recurrent GBM treated at dose of 36 Gy in 2-Gy fractions in combination with TMZ, the reported median OS and PFS from re-irradiation were 8 and 5 months, respectively . Grosu et al. reported a median survival time of 11 months for patients who have received fractionated stereotactic radiation therapy plus TMZ, while a survival time of 6 months was reached by patients treated with fractionated stereotactic radiation therapy without TMZ (p=0.0008) . Literature is sparse regarding the toxicity of hypo-fractionated stereotactic radiotherapy in recurrent GBM. Some studies reported higher rates of necrosis but because of the wide range of delivered doses the data are inconclusive. However, the comparison of different studies of re-irradiation remains difficult because of the variability in target definition, treatment technique, fractionation schema, use of concomitant chemotherapy and initial patient characteristics. In the management of GB, the pattern of failure is one of the major concerns in relation to the clinical target volume margins, optimal radiation dose, and identification of biomarkers. In the majority of reported series, local progression after initial management was encountered in 60% to 97% of cases, but comparison of different studies is difficult due to differences in treatment strategy, extension of surgical removal, postoperative surveillance, length of follow up as well as definition and categorization of the tumor progression. Several studies have shown that the majority of patients with GBM treated with RT plus concomitant and adjuvant temozolomide have central recurrences [65–68]. Furthermore, many previous trials found that the type of local recurrence in relation to the radiation fields ("in field", "marginal" or "out-field" recurrence) was associated with impaired prognosis [68–73]. In particular, the median survival was 17.3, 14.8 and 26.1 months in patients with recurrence inside, at the margin and outside the irradiation field .
The objective of the current study is to evaluate retrospectively the efficacy and the safety of the re-irradiation of patients with recurrent GBM in comparison with other salvage approaches. The patients of the study were part of a consecutive series of 91 patients previously treated with standard RT and TMZ.
In our series the pattern of recurrences evaluated in 71 cases was : "in-field" recurrence in 51 patients (73%), marginal recurrence in 7 patients (9%) and "out-of-field" recurrence in 13 patients (17%). At tumor recurrence/progression, only 15 and 6 patients received a salvage radiation treatment or a re-operation, respectively. The remaining 50 patients with disease progression had been considered un-fit for local therapy and received a second line chemotherapy (37 patients) or the best supportive care (13 patients). The median survival time after diagnosis of tumor recurrence in the group of patients treated with re-irradiation (9.5 months) was significantly longer than that who received best supportive care (2.5 months, p=0.0001) and which has had a longer trend compared to that of patients treated with chemotherapy of second line(5.5 months, p=0.049). Furthermore, we have found that patients treated with re-irradiation at the time of tumor recurrence has had the longest overall survival from the time of initial diagnosis (33 months, p=0.000049). However, we can not exclude that this finding may result from selection bias for application of the different types of salvage treatment. Also the patients who underwent re-surgery show to survive less than re-irradiated patients (median OS 33 vs 17 months respectively, p= 0.00034). We did not found a significant correlation between the OS and the pattern of failure, although in the group of patients with "in-field" rather than outside progression a mild tendency to a better OS was observed.. This trend might reflect an other selection bias, due to the possible inclusion of some cases of pseudo-progression erroneously interpreted as local recurrence.
With regard to the time interval between the first to the second irradiation, we found a positive but not significant correlation between longer interval and survival after re-irradiation.
Unfortunately, our study represents a retrospective analysis and patients at the time of tumor recurrence were not randomized to one or the other salvage treatment. In addition, the indication for the salvage treatment and the choice of which perform (surgery, re-irradiation, chemotherapy) was evaluated by our interdisciplinary neuro-oncology team (and from the patient preferences too). The clinical and tumoral features that have guided their decision were mainly: the patient clinical condition (i.e. KPS> 70), the lesion location and the spread of disease. This means that patients with up-front worse prognosis were excluded from the re-irradiation. Stratifying for these characteristics, the analysis of all patients showed no differences between the groups of different salvage strategies and did not allow the identification of factors associated with choice of one or other salvage treatment. On the basis of these considerations, it was not possible to match the patients included in these groups and therefore the drawing of any conclusions regarding the efficacy of each treatment modality it can suffer of some bias and/or arbitrary.
On the other hand, our results confirm the feasibility and safety of re-irradiation in recurrent GBM. In fact, in our population, although it is a small series, re-irradiation was not accompanied by any case of significant morbidity or side effect. Literature is sparse regarding the toxicity of hypo-fractionated stereotactic radiotherapy in recurrent GBM. Previous studies reported higher rates of necrosis but have utilized a wide range of doses. An association has been noted between higher rates of re-operation and doses greater than 40 Gy [59, 74]. With the limitations of the data now at our disposal, radiation therapy for recurrent GBM after standard therapy seems to be safe and in our study the re-irradiated patients have a longer OS compared to patients treated with other approaches.
Our study shows that hypo-fractionated stereotactic radiation therapy is effective and safe in recurrent GBM after conventional chemo-radiation treatment, even if the dose response and dose limits remain unclear. Anyway, until prospective randomized trials will confirm these results, the decisions for salvage re-irradiation should be based on multidisciplinary evaluation and personalized on the patient.
- Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005, 352: 987-996. 10.1056/NEJMoa043330View ArticlePubMedGoogle Scholar
- van den Bent MJ, Brandes AA, Rampling R, et al.: Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurret glioblastoma: EORTC Brain Tumor Group study 26034. J Clin Oncol 2009,27(8):1268-1274. 10.1200/JCO.2008.17.5984View ArticlePubMedPubMed CentralGoogle Scholar
- Brandes AA, Tosoni A, Amista P, et al.: How effective is BCNU in recurrent glioblastoma in the modern era? A phase II trial. Neurology 2004,63(7):1281-1284. 10.1212/01.WNL.0000140495.33615.CAView ArticlePubMedGoogle Scholar
- Reithmeier T, Graf E, Piroth T, Trippel M, Pinsker MO, et al.: BCNU for recurrent glioblastoma multiforme: efficacy, toxicity and prognostic factord. BMC Cancer 2010 Feb 2, 10: 30. 10.1186/1471-2407-10-30View ArticlePubMedPubMed CentralGoogle Scholar
- Batchelor T, Mulholland P, Neyns B, et al.: The efficacy of cediranib as monotherapy and in combination with lomustine compared to lomustine alone in patients with recurrent glioblastoma: a phase III randomized trial. Neuro Oncol 2010,12(Suppl. 4):75.Google Scholar
- Happold C, Roth P, Wick W, et al.: ACNU-based chemotherapy for recurrent glioma in the temozolomide era. J Neurooncol 2009,92(1):45-48. 10.1007/s11060-008-9728-9View ArticlePubMedGoogle Scholar
- Addeo R, Caraglia M, De Santi MS, et al.: A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma. J Neuroncol 2011,102(3):417-424. 10.1007/s11060-010-0329-zView ArticleGoogle Scholar
- Scoccianti S, Detti B, Sardaro A, et al.: Second-line chemotherapy with fotemustine in temozolomide-pretreated patients with relapsing glioblastoma: a single institution experience. Anticancer Drugs 2008,19(6):613-620. 10.1097/CAD.0b013e3283005075View ArticlePubMedGoogle Scholar
- Brada M, Hoang-Xuan K, Rampling R, et al.: Randomized phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse. Ann Oncol 2001, 1282: 259-266.View ArticleGoogle Scholar
- Brandes AA, Ermani M, Basso U, et al.: Temozolomide as a second-line sistemi regimen in recurrent high-grade glioma: a phase II study. Ann Oncol 2011,12(2):255-257.View ArticleGoogle Scholar
- Brandes AA, Ermani M, Basso U, et al.: Temozolomide in patients with glioblastoma at second relapse after first line nitrosurea-procarbazine failure: a phase II study. Oncology 2002,63(1):38-41. 10.1159/000065718View ArticlePubMedGoogle Scholar
- Khan RB, Raizer JJ, Malkin MG, et al.: A phase II study of extended low-dose temozolomide in recurrent malignant gliomas. Neuro Oncol 2002,4(1):39-43.View ArticlePubMedPubMed CentralGoogle Scholar
- Brandes AA, Tosoni A, Cavallo G, et al.: Temozolomide 3 weeks on and 1 week off as first-line therapy for recurrent glioblastoma: phase II study from Gruppo Italiano Cooperativo di Neuro-oncologia (GICNO). Br J Cancer 2006,95(9):1155-1160. 10.1038/sj.bjc.6603376View ArticlePubMedPubMed CentralGoogle Scholar
- Balmaceda C, Peereboom D, Pannullo S, et al.: Multi-institutional phase II study of temozolomide administered twice daily in the treatment of recurrent high-grade gliomas. Cancer 2008,112(5):1139-1146. 10.1002/cncr.23167View ArticlePubMedGoogle Scholar
- Wick W, Steinbach JP, Kuker WM, et al.: One week on/one week off: a novel active regimen of temozolomide for recurrent glioblastoma. Neurology 2004,62(11):2113-2115. 10.1212/01.WNL.0000127617.89363.84View ArticlePubMedGoogle Scholar
- Yung WK, Albright RE, Olson J, et al.: A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse. Br J Cancer 2000,83(5):588-593. 10.1054/bjoc.2000.1316View ArticlePubMedPubMed CentralGoogle Scholar
- Franceschi E, Omuro AM, Lassman AB, Demopoulos A, et al.: Salvage temozolomide for prior temozolomide responders. Cancer 2005,104(11):2473-2476. 10.1002/cncr.21564View ArticlePubMedGoogle Scholar
- Kong DS, Lee JI, Kim WS, et al.: A pilot study of metronomic temozolomide treatment in patients with recurrent temozolomide-refractory glioblastoma. Oncol Rep 2006,16(5):117-1121.Google Scholar
- Berrocal A, Perez Segura P, Gil M, et al.: Extended-schedule dose-dense temozolomide in refractory gliomas. J Neuroncol 2010,96(3):417-422. 10.1007/s11060-009-9980-7View ArticleGoogle Scholar
- Kong DS, Lee JI, Kim JH, et al.: Phase II trial of low-dose continuous (metronomic) treatment of temozolomide for recurrent glioblastoma. Neuro Oncol 2010,12(3):289-296. 10.1093/neuonc/nop030View ArticlePubMedPubMed CentralGoogle Scholar
- Hammond A, Norden AD, Lesser GJ, et al.: Phase II study of dose-intense temozolomide in recurrent gliblastoma. J Clin Oncol 2038, 2011: 29.Google Scholar
- Park JK, Hodges T, Arko L, et al.: Scale to predict survival after surgery for recurrent glioblastoma multiforme. J Clin Oncol 2010,28(24):3838-3843. 10.1200/JCO.2010.30.0582View ArticlePubMedPubMed CentralGoogle Scholar
- Barbagallo GM, Jenkinson MD, Brodbelt AR: Recurrent Gliobastoma multiforme- when should we reoperate? Br J Neurosurg 2008,22(3):452-455. 10.1080/02688690802182256View ArticlePubMedGoogle Scholar
- Dhermain F, de Crevoisier R, Parker F, Cioloca C, Kaliski A, Beaudre A, Lefkopoulos D, Armand JP, Haie-Meder C: Role of radiotherapy in recurrent gliomas. Bull Cancer 2004,91(11):883-889.PubMedGoogle Scholar
- Coombs SE, Debus J, Shulz-Ertner D: Radiotherapeutic alternatives for previously irradiated recurrent gliomas. BMC Cancer 2007, 7: 167. 10.1186/1471-2407-7-167View ArticleGoogle Scholar
- Hall WA, Djalilian HR, Sperduto PW, et al.: Stereotactic radiosurgery for recurrent malignant gliomas. J Clin Oncol 1995, 13: 1642-1648.PubMedGoogle Scholar
- Cabrera AR, Cuneo KC, Vredenburgh JJ, et al.: Stereotactic radiosurgery and bevacizumab for recurrent glioblastoma multiforme. J Natl Compr Canc Netw 2012 Jun 1,10(6):695-699.PubMedGoogle Scholar
- Combs SE, Widmer V, Thilmann C, et al.: Stereotactic radiosurgery (SRS): treatment option for recurrent glioblastoma multiforme (GBM). Cancer 2005, 104: 2168-2173. 10.1002/cncr.21429View ArticlePubMedGoogle Scholar
- Patel M, Siddiqui F, Jin JY, Mikkelsen T, et al.: Salvage reirradiation for recurrent glioblastoma with radiosurgery: radiographic response and improved survival. J Neurooncol 2009, 92: 185-191. 10.1007/s11060-008-9752-9View ArticlePubMedGoogle Scholar
- Cho KH, Hall WA, Gerbi BJ, Higgins PD, et al.: Single dose versus fractionated stereotactic radiotherapy for recurrent high-grade gliomas. Int J Radiat Oncol Biol Phys 1999, 45: 1133-1141. 10.1016/S0360-3016(99)00336-3View ArticlePubMedGoogle Scholar
- Combs SE, Gutwein S, Thilman CH, et al.: Stereotactically guided fractionated reirradiation in recurrent glioblastoma multiforme. J Neurooncol 2005, 74: 167-171. 10.1007/s11060-004-2463-yView ArticlePubMedGoogle Scholar
- Combs SE, Thilman CH, Edler L, et al.: Efficacy of fractionated stereotactic reiraddiation in recurrent gliomas: long-term result in 172 patients treated in a single institution. J Clin Oncol 2005, 23: 8863-8869. 10.1200/JCO.2005.03.4157View ArticlePubMedGoogle Scholar
- Vordermark D, Kolbl O, Ruprecht K, et al.: Hypofractionated stereotactic re-irradiarion: treatment option in recurrent malignant glioma. BMC Cancer 2005, 5: 55. 10.1186/1471-2407-5-55View ArticlePubMedPubMed CentralGoogle Scholar
- Lederman G, Wronski M, Arbit E, et al.: Treatment of recurrent glioblastoma multiforme using fractionated stereotactic radiosurgery and concurrent paclitaxel. Am J Clin Oncol 2000, 23: 155-159. 10.1097/00000421-200004000-00010View ArticlePubMedGoogle Scholar
- Arcicasa M, Roncadin M, Bidoli E, et al.: Reirradiation and lomustine in patients with relapsed high-grade gliomas. Int J Radiat Oncol Biol Phys 1999, 43: 789-793. 10.1016/S0360-3016(98)00457-XView ArticlePubMedGoogle Scholar
- Combs SE, Bischof M, Welzel T, et al.: Radiochemotherapy with temozolomide as re-irradiation using high precision fractionated stereotactic radiotherapy (FSRT) in patients with recurrent gliomas. J Neurooncol 2008, 89: 205-210. 10.1007/s11060-008-9607-4View ArticlePubMedGoogle Scholar
- Minniti G, Armosini V, Salvati M, et al.: Fractionated stereotactic reirradiation and concurrent temozolomide in patients with recurrent glioblastoma. J Neurooncol 2011,103(3):683-691. 10.1007/s11060-010-0446-8View ArticlePubMedGoogle Scholar
- Louis DN, Ohgaki H, Wiestler OD, Cavenee WK: WHO Classification of Tumours of the Central Nervous System. IARC: Lyon; 2007.Google Scholar
- Lee SW, Fraas BA, Marsh LH, et al.: Patterns of failure following hig-dose 3-D conformal radiotherapy for high-grade astrocytomas: A quantitative dosimetric study. Int J Radiat Oncol Biol Phys 1999,43(199):79-88.View ArticlePubMedGoogle Scholar
- Ammirati M, Galicich JH, Arbit E, Liao Y: Reoperation in the treatment of recurrent intracranial malignant gliomas. Neurosurgery 1987, 21: 607-614. 10.1227/00006123-198711000-00001View ArticlePubMedGoogle Scholar
- Hou LC, Veeravagu A, Hsu AR, Tse VC: Recurrent glioblastoma multiforme: a review of natural history and management options. Neurosurgical focus 2006, 20: E5.View ArticlePubMedGoogle Scholar
- Nieder C, Grosu AL, Molls M: A comparison of treatment results for recurrent malignant gliomas. Cancer Treat Rev 2000, 26: 397-409. 10.1053/ctrv.2000.0191View ArticlePubMedGoogle Scholar
- Stupp R, Hegi ME, Gilbert MR, et al.: Chemoradiotherapy in malignant glioma: standard of care and future directions. J Clin Oncol 2007, 25: 4127-4136. 10.1200/JCO.2007.11.8554View ArticlePubMedGoogle Scholar
- Brandes AA, Franceschi E, Tosoni A, Bartolini S, Bacci A, Agati R, et al.: O(6)-methylguanine DNA-methyltransferase methyleation status can change between first surgery for newly diagnosed glioblastoma and second surgery from recurrence: clinical implications. Neuro Oncol 2010, 12: 283-288. 10.1093/neuonc/nop050View ArticlePubMedPubMed CentralGoogle Scholar
- Vredenburgh JJ, Desjardinis A, Herndon JE 2nd, et al.: Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol 2007, 25: 4722-4729. 10.1200/JCO.2007.12.2440View ArticlePubMedGoogle Scholar
- Young B, Oldfield EH, Markesbery WR, Haack D, Tibbs P, McCoombs P, et al.: Reoperation for glioblastoma. J Neurosurg 1981, 55: 917-921. 10.3171/jns.1981.55.6.0917View ArticlePubMedGoogle Scholar
- Barker FG 2nd, Chang SM, Gutin PH, Malec MK, McDermott MW, Prados MD, et al.: Survival and functional status after resection of recurrent glioblastoma multiforme. Neurosurgery 1998, 42: 709-720. 10.1097/00006123-199804000-00013View ArticlePubMedGoogle Scholar
- Sirin S, Oysul K, Surenkok S, et al.: Linear accelerator-based stereotactic radiosurgery in recurrent glioblastoma: a single center experience. Vojnosanit Pregl 2011,68(11):961-6. 10.2298/VSP1111961SView ArticlePubMedGoogle Scholar
- Simon JM, Cornu P, Boisserie G, et al.: Brachytherapy of glioblastoma recurring in previously irradiated territory: predictive value of tumor volume. Int J Radiat Oncol Biol Phys 2002, 53: 67-74. 10.1016/S0360-3016(01)02804-8View ArticlePubMedGoogle Scholar
- Chan TA, Weingart JD, Parisi M, et al.: Treatment of recurrent glioblastoma multiforme with GliaSite brachytherapy. Int J Radiat Oncol Biol Phys 2005, 62: 1133-1139. 10.1016/j.ijrobp.2004.12.032View ArticlePubMedGoogle Scholar
- Larson DA, Prados M, Lamborn KR, et al.: Phase II study of high central dose gamma knife radiosurgery and marimastat in patients with recurrent malignant glioma. Int J Radiat Oncol Biol Phys 2002, 54: 1397-1404. 10.1016/S0360-3016(02)03743-4View ArticlePubMedGoogle Scholar
- Shrieve DC, Alexander E 3rd, Wen PY, et al.: Comparison of stereotactic radiosurgery and brachytherapy in the treatment of recurrent glioblastoma multiforme. Neurosurgery 1995, 36: 275-282. discussion 282–4 10.1227/00006123-199502000-00006View ArticlePubMedGoogle Scholar
- Grosu AL, Weber WA, Franz M, et al.: Reirradiation of recurrent high-grade gliomas using amino acid PET (SPECT)/CT/MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy. Int J Radiat Oncol Biol Phys 2005, 63: 511-519. 10.1016/j.ijrobp.2005.01.056View ArticlePubMedGoogle Scholar
- Kohshi K, Yamamoto H, Nakahara A, et al.: Fractionated stereotactic radiotherapy using gamma unit after hyperbaric oxygenation on recurrent high-grade gliomas. J Neurooncol 2007, 82: 297-303. 10.1007/s11060-006-9283-1View ArticlePubMedGoogle Scholar
- Ernst-Stecken A, Ganslandt O, Lambrecht U, Sauer R, Grabenbauer G: Survival and quality of life after hypofractionated stereotactic radiotherapy for recurrent malignant glioma. J Neurooncol 2007, 81: 287-294. 10.1007/s11060-006-9231-0View ArticlePubMedGoogle Scholar
- Fokas E, Wacker U, Gross MW, Henzel M, Encheva E, Engenhart-Cabillic R: Hypofractionated stereotactic reirradiation of recurrent glioblastomas: a beneficial treatment option after high-dose radiotherapy? Strahlenther Onkol 2009, 185: 235-240. 10.1007/s00066-009-1753-xView ArticlePubMedGoogle Scholar
- Henke G, Paulsen F, Steinbach JP, Ganswindt U, Isijanov H, Kortmann RD, Bamberg M, Belka C: Hypofractionated reirradiation for recurrent malignant glioma. Strahlenther Onkol 2009, 185: 113-119. 10.1007/s00066-009-1969-9View ArticlePubMedGoogle Scholar
- Fogh SE, Anrews DW, Glass J, Curran W, Glass C, Champ C, Evans JJ, Hyslop T, Pequignot E, Downes B, Comber E, Maltenfort M, Dicker AP, Werner-Wasik M: Hypofractionated stereotactic radiation therapy: an effective therapy for recurrent high-grade gliomas. J Clin Oncol 2010, 28: 3048-3053. 10.1200/JCO.2009.25.6941View ArticlePubMedPubMed CentralGoogle Scholar
- Shepherd SF, Laing RW, Cosgrove VP, Warrington AP, Hines F, Ashley SE, Brada M: Hypofractionated stereotactic radiotherapy in the management of recurrent glioma. Int J Radiat Oncol Biol Phys 1997, 37: 393-398. 10.1016/S0360-3016(96)00455-5View ArticlePubMedGoogle Scholar
- Glass J, Silverman CL, Axelrod R, Corn BW, Andrews DW: Fractionated stereotactic radiotherapy with cis-platinum radiosensitization in the treatment of recurrent, progressive or persistent malignant astrocytoma. Am J Clin Oncol 1997, 20: 226-229. 10.1097/00000421-199706000-00002View ArticlePubMedGoogle Scholar
- Hudes RS, Corn BW, Werner-Wasik M, Andrews D, Rosenstock J, Thoron L, Downes B, Curran WJ: A phase I dose escalation study of hypofractionated stereotactic radiotherapy as salvage therapy for persistent or recurrent malignant glioma. Int J Radiat Oncol Biol Phys 1999, 43: 291-298.View ArticleGoogle Scholar
- Voynov G, Kaufman S, Hong T, Pinkerton A, Simon R, Dowsett R: Treatment of recurrent malignant gliomas with stereotactic intensity modulated radiation therapy. Am J Clin Oncol 2002, 25: 606-611. 10.1097/00000421-200212000-00017View ArticlePubMedGoogle Scholar
- Veninga T, Langendijk HA, Slotman BJ, et al.: Reirradiation of primary brain tumors: serviva, clinical response and prognostic factors. Rdaiother Oncol 2001, 59: 127-137. 10.1016/S0167-8140(01)00299-7View ArticleGoogle Scholar
- Nieder C, Astner ST, Mehta MP, et al.: Improvement, clinical course, and quality of life after palliative radiotherapy for recurrent glioblastoma. Am J Clin Oncol 2008, 31: 300-305. 10.1097/COC.0b013e31815e3fdcView ArticlePubMedGoogle Scholar
- Chang EL, Akurek S, Avalos T, et al.: Evaluation of peritumoral edema in the delineation of radiotherapy clinical target volumes for glioblastoma. Int J Radiat Oncol Biol Phys 2007, 86: 144-150.View ArticleGoogle Scholar
- Liang BC, Thornton AF Jr, Sandler HM, et al.: Malignant atrocytomas: focal tumor recurrence after local external beam radiation therapy. J Neurosurg 1991, 75: 559-563. 10.3171/jns.1991.75.4.0559View ArticlePubMedGoogle Scholar
- Lee SW, Fraass BA, Marsh LH, et al.: Patterns of failure following high-dose 3-D conformal radiotherapy for high-grade astrocytomas: A quantitative dosimetric study. Int J Radiat Oncol Biol Phys 1999, 43: 79-88. 10.1016/S0360-3016(98)00266-1View ArticlePubMedGoogle Scholar
- McDonald MW, Shu HK, Curran WJ, et al.: Pattern of failure after limited margin radiotherapy and temozolomide for glioblastoma. Int J Radiat Oncol Biol Phys 2011, 79: 130-136. 10.1016/j.ijrobp.2009.10.048View ArticlePubMedGoogle Scholar
- Minniti G, Amelio D, Amichetti M, et al.: Patterns of failure and comparison of different target volume delineations in patients with gliobalstoma treated with conformal radiotherapy plus concomitant and adjuvant temozolomide. Rdaiother Oncol 2010, 97: 377-381. 10.1016/j.radonc.2010.08.020View ArticleGoogle Scholar
- Milano MT, Okunieff P, Donatello RS, et al.: Patterns and timing of recurrence after temozolomide-based chemoradiation for glioblastoma. Int J Radiat Oncol Biol Phys 2010, 78: 1147-1155. 10.1016/j.ijrobp.2009.09.018View ArticlePubMedGoogle Scholar
- Brandes AA, Tosoni A, Franceschi E, et al.: Recurrence pattern after temozolomide concomitant with and ajuvant to radiotherapy in newly diagnosed patients with glioblastoma: correlation with MGMT promoter methylation status. J Clin Oncol 2009, 27: 1275-1279. 10.1200/JCO.2008.19.4969View ArticlePubMedGoogle Scholar
- Hochberg FH, Pruitt A: Assumption in the radiotherapy glioblastoma. Neurology 1980, 30: 907-911. 10.1212/WNL.30.9.907View ArticlePubMedGoogle Scholar
- Stewart LA: Chemotherapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 2002, 359: 1011-1018.View ArticlePubMedGoogle Scholar
- Laing RW, Warrington AP, Graham J, et al.: Efficacy and toxicity of fractionated stereotactic radiotherapy in the treatment of recurrent gliomas (Phase I/II study). Radiother Oncol 1993, 27: 22-29. 10.1016/0167-8140(93)90040-FView ArticlePubMedGoogle Scholar
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