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  1. Research

    Preoperative intensity-modulated radiotherapy with a simultaneous integrated boost combined with Capecitabine in locally advanced rectal cancer: short-term results of a multicentric study

    Preoperative radiotherapy (RT) in combination with fluoropyrimidine-based chemotherapy (CT) is the standard of care in patients with locally advanced, T3-T4 N0–2, rectal cancer (LARC). Given the correlation be...

    Marco Lupattelli, Fabio Matrone, Maria Antonietta Gambacorta, Mattia Osti, Gabriella Macchia, Elisa Palazzari, Luca Nicosia, Federico Navarria, Giuditta Chiloiro, Vincenzo Valentini, Cynthia Aristei and Antonino De Paoli

    Radiation Oncology 2017 12:139

    Published on: 22 August 2017

  2. Research

    The feasibility analysis of omission of elective irradiation to level IB lymph nodes in low-risk nasopharyngeal carcinoma based on the 2013 updated consensus guideline for neck nodal levels

    Level IB metastasis is rare in nasopharyngeal carcinoma (NPC). The purpose of this study is to investigate the high-risk factors for level IB metastasis and evaluate the feasibility of omission of elective irr...

    Xiaomin Ou, Yibing Miao, Xiaoshen Wang, Jianhui Ding, Xiayun He and Chaosu Hu

    Radiation Oncology 2017 12:137

    Published on: 18 August 2017

  3. Study protocol

    Hypo-fractionated SBRT for localized prostate cancer: a German bi-center single treatment group feasibility trial

    For prostate cancer treatment, treatment options with minimal side effects are desired. External beam radiation therapy (EBRT) is non-invasive, standard of care and delivered in either conventional fractionati...

    Ping Jiang, Katja Krockenberger, Reinhard Vonthein, Jane Tereszczuk, Arne Schreiber, Sebastian Liebau, Stefan Huttenlocher, Detlef Imhoff, Panagiotis Balermpas, Christian Keller, Kathrin Dellas, Rene Baumann, Claus Rödel, Guido Hildebrandt, Klaus-Peter Jünemann, Alex S. Merseburger…

    Radiation Oncology 2017 12:138

    Published on: 18 August 2017

  4. Research

    Radiotoxicity in robotic radiosurgery: proposing a new quality index for optimizing the treatment planning of brain metastases

    As irradiated brain volume at 12 Gy (V12) is a predictor for radionecrosis, the purpose of the study was to develop a model for Cyberknife (CK) plans that is able to predict the lowest achievable V12 at a give...

    Alexandra Hellerbach, Klaus Luyken, Mauritius Hoevels, Andreas Gierich, Daniel Rueß, Wolfgang W. Baus, Martin Kocher, Maximilian I. Ruge and Harald Treuer

    Radiation Oncology 2017 12:136

    Published on: 17 August 2017

  5. Research

    Comparison of photon volumetric modulated arc therapy, intensity-modulated proton therapy, and intensity-modulated carbon ion therapy for delivery of hypo-fractionated thoracic radiotherapy

    The aim of the present study was to compare the dose distribution generated from photon volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT), and intensity modulated carbon ion th...

    Alexander Chi, Lien-Chun Lin, Sijin Wen, Haijuan Yan and Wen-Chien Hsi

    Radiation Oncology 2017 12:132

    Published on: 15 August 2017

  6. Research

    Patterns of locoregional failure following post-operative intensity-modulated radiotherapy to oral cavity cancer: quantitative spatial and dosimetric analysis using a deformable image registration workflow

    We sought to identify spatial/dosimetric patterns of failure for oral cavity cancer patients receiving post-operative IMRT (PO-IMRT).

    Abdallah S. R. Mohamed, Andrew J. Wong, Clifton D. Fuller, Mona Kamal, Gary B. Gunn, Jack Phan, William H. Morrison, Beth M. Beadle, Heath Skinner, Stephen Y. Lai, Sean R. Quinlan-Davidson, Abdelaziz M. Belal, Ahmed G. El-Gowily, Steven J. Frank, David I. Rosenthal and Adam S. Garden

    Radiation Oncology 2017 12:129

    Published on: 15 August 2017

  7. Research

    Understanding the potentiality of accelerator based-boron neutron capture therapy for osteosarcoma: dosimetry assessment based on the reported clinical experience

    Osteosarcoma is the most frequent primary malignant bone tumour, and its incidence is higher in children and adolescents, for whom it represents more than 10% of solid cancers. Despite the introduction of adju...

    Silva Bortolussi, Ian Postuma, Nicoletta Protti, Lucas Provenzano, Cinzia Ferrari, Laura Cansolino, Paolo Dionigi, Olimpio Galasso, Giorgio Gasparini, Saverio Altieri, Shin-Ichi Miyatake and Sara J. González

    Radiation Oncology 2017 12:130

    Published on: 15 August 2017

  8. Research

    Factors affecting survival after concurrent chemoradiation therapy for advanced hepatocellular carcinoma: a retrospective study

    Concurrent chemoradiation therapy (CCRT) followed by hepatic arterial infusional chemotherapy (HAIC) was reported to be effective for advanced hepatocellular carcinoma (HCC) with portal vein thrombosis. Howeve...

    Ja Kyung Kim, Jun Won Kim, Ik Jae Lee, Seung-Moon Joo, Kwang-Hun Lee, Eun-Suk Cho, Jeong-Sik Yu, Tae Joo Jeon, Yonsoo Kim, Jung Il Lee and Kwan Sik Lee

    Radiation Oncology 2017 12:133

    Published on: 15 August 2017

  9. Research

    Outcome of hearing preservation related to tumor morphologic analysis in acoustic neuromas treated by gamma knife radiosurgery

    Gamma Knife radiosurgery (GKRS) is an important part of the neurosurgical armamentarium in the treatment of acoustic neuromas. However, the treatment outcome related to the morphology of the tumor has not been...

    Szu-Yen Pan, Shih-An Liu, Ming-Hsi Sun, Hsi-Kai Tsou, Shinh-Dung Lee, Yen-Ju Chen, Jason Sheehan, Meei-Ling Sheu and Hung-Chuan Pan

    Radiation Oncology 2017 12:134

    Published on: 15 August 2017

  10. Research

    Intensity-modulated versus 3-dimensional conformal radiotherapy in the definitive treatment of esophageal cancer: comparison of outcomes and acute toxicity

    Though the vast majority of seminal trials for locally advanced esophageal cancer (EC) utilized three-dimensional conformal radiotherapy (3DCRT), the advanced and highly conformal technology known as intensity...

    Matthias Felix Haefner, Kristin Lang, Vivek Verma, Stefan Alexander Koerber, Lorenz Uhlmann, Juergen Debus and Florian Sterzing

    Radiation Oncology 2017 12:131

    Published on: 15 August 2017

  11. Research

    Neurocognitive sparing of desktop microbeam irradiation

    Normal tissue toxicity is the dose-limiting side effect of radiotherapy. Spatial fractionation irradiation techniques, like microbeam radiotherapy (MRT), have shown promising results in sparing the normal brai...

    Soha Bazyar, Christina R. Inscoe, Thad Benefield, Lei Zhang, Jianping Lu, Otto Zhou and Yueh Z. Lee

    Radiation Oncology 2017 12:127

    Published on: 11 August 2017

  12. Research

    Risk adapted dose-intensified postoperative radiation therapy in prostate cancer patients using a simultaneous integrated boost technique applied with helical Tomotherapy

    Postoperative adjuvant radiation therapy (ART) in T3 and R1 prostate cancer as well as salvage radiation therapy (SRT) in case of postoperative biochemical failure (BF) are established treatments. Dose-intensi...

    Marcus Beck, Peter Wust, Tomasz Barelkowski, David Kaul, Alexander-Henry Thieme, Sascha Wecker, Waldemar Wlodarczyk, Volker Budach and Pirus Ghadjar

    Radiation Oncology 2017 12:125

    Published on: 10 August 2017

  13. Research

    A novel CBCT-based method for derivation of CTV-PTV margins for prostate and pelvic lymph nodes treated with stereotactic ablative radiotherapy

    Traditional CTV-PTV margin recipes are not generally applicable in the situation of stereotactic ablative radiotherapy (SABR) treatments of multiple target volumes with a single isocentre. In this work, we pre...

    Ciara A. Lyons, Raymond B. King, Sarah O.S. Osman, Stephen J. McMahon, Joe M. O’Sullivan, Alan R. Hounsell, Suneil Jain and Conor K. McGarry

    Radiation Oncology 2017 12:124

    Published on: 4 August 2017

  14. Research

    Application of the new 8th TNM staging system for non-small cell lung cancer: treated with curative concurrent chemoradiotherapy

    The eighth tumor, node, metastasis (TNM) staging system (8-TNM) for non-small cell lung cancer (NSCLC) was newly released in 2015. This system had limitation because most patients included in the analysis were...

    Hoon Sik Choi, Bae Kwon Jeong, Hojin Jeong, Yun Hee Lee, In Bong Ha, Jin Ho Song and Ki Mun Kang

    Radiation Oncology 2017 12:122

    Published on: 21 July 2017

  15. Research

    Clinical workflow for MR-only simulation and planning in prostate

    To describe the details and experience of implementing a MR-only workflow in the clinic for simulation and planning of prostate cancer patients.

    Neelam Tyagi, Sandra Fontenla, Michael Zelefsky, Marcia Chong-Ton, Kyle Ostergren, Niral Shah, Lizette Warner, Mo Kadbi, Jim Mechalakos and Margie Hunt

    Radiation Oncology 2017 12:119

    Published on: 17 July 2017

  16. Research

    Biomarkers of resistance to radiation therapy: a prospective study in cervical carcinoma

    Clinical parameters and proteins have recently been suggested as possible causes of radiotherapy (RT) resistance in cervical carcinoma (CC). The objective of the present study was to validate prognostic biomar...

    P. Moreno-Acosta, A. Vallard, S. Carrillo, O. Gamboa, A. Romero-Rojas, M. Molano, J. Acosta, D. Mayorga, C. Rancoule, M.A. Garcia, M. Cotes Mestre and N. Magné

    Radiation Oncology 2017 12:120

    Published on: 17 July 2017

  17. Research

    Analyses of distribution and dosimetry of brain metastases in small cell lung cancer with relation to the neural stem cell regions: feasibility of sparing the hippocampus in prophylactic cranial irradiation

    This work aims to assess the feasibility of selectively sparing the hippocampus during prophylactic cranial irradiation (PCI) for small cell lung cancer (SCLC).

    Lei Zhao, Yan Shen, Jin-Dong Guo, Heng-Le Gu, Wen Yu, Jia-Ming Wang, Chang-Xing LV, Jun Liu, Xu-Wei Cai and Xiao-Long Fu

    Radiation Oncology 2017 12:118

    Published on: 15 July 2017

  18. Research

    Investigation of irradiated volume in linac-based brain hypo-fractionated stereotactic radiotherapy

    Emerging techniques such as brain hypo-fractionated radiotherapy (HF-RT) involve complex cases with limited guidelines for plan quality and normal tissue tolerances. The purpose of the present study was to sta...

    Mark Ruschin, Arjun Sahgal, Hany Soliman, Sten Myrehaug, May Tsao, Collins Yeboah, Arman Sarfehnia, Brige Chugh, Alex Kiss and Young Lee

    Radiation Oncology 2017 12:117

    Published on: 14 July 2017

  19. Research

    Excellent local control and tolerance profile after stereotactic body radiotherapy of advanced hepatocellular carcinoma

    To evaluate the efficacy and toxicity of stereotactic body radiotherapy (SBRT) in the treatment of advanced hepatocellular carcinoma (HCC).

    Eleni Gkika, Michael Schultheiss, Dominik Bettinger, Lars Maruschke, Hannes Philipp Neeff, Michaela Schulenburg, Sonja Adebahr, Simon Kirste, Ursula Nestle, Robert Thimme, Anca-Ligia Grosu and Thomas Baptist Brunner

    Radiation Oncology 2017 12:116

    Published on: 12 July 2017

  20. Research

    Spinal bone metastases in colorectal cancer: a retrospective analysis of stability, prognostic factors and survival after palliative radiotherapy

    This retrospective analysis aimed to analyse the stability of spinal bone metastases in colorectal cancer (CRC) patients following radiotherapy (RT) by use of a validated score and to assess prognostic factors...

    Tilman Bostel, Robert Förster, Ingmar Schlampp, Tania Sprave, Thomas Bruckner, Nils Henrik Nicolay, Stefan Ezechiel Welte, Jürgen Debus and Harald Rief

    Radiation Oncology 2017 12:115

    Published on: 11 July 2017

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