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  1. Research

    Exclusion of emphysematous lung from dose-volume estimates of risk improves prediction of radiation pneumonitis

    The risk factors for radiation pneumonitis (RP) in patients with chronic obstructive pulmonary disease (COPD) are unclear. Mean lung dose (MLD) and percentage of irradiated lung volume are common predictors of...

    Yasuki Uchida, Takuya Tsugawa, Sachiko Tanaka-Mizuno, Kazuo Noma, Ken Aoki, Wataru Shigemori, Hiroaki Nakagawa, Daisuke Kinose, Masafumi Yamaguchi, Makoto Osawa, Emiko Ogawa and Yasutaka Nakano

    Radiation Oncology 2017 12:160

    Published on: 2 October 2017

  2. Research

    CT imaging features associated with recurrence in non-small cell lung cancer patients after stereotactic body radiotherapy

    Predicting recurrence after stereotactic body radiotherapy (SBRT) in non-small cell lung cancer (NSCLC) patients is problematic, but critical for the decision of following treatment. This study aims to investi...

    Qian Li, Jongphil Kim, Yoganand Balagurunathan, Jin Qi, Ying Liu, Kujtim Latifi, Eduardo G. Moros, Matthew B. Schabath, Zhaoxiang Ye, Robert J. Gillies and Thomas J. Dilling

    Radiation Oncology 2017 12:158

    Published on: 25 September 2017

  3. Research

    Comparative study of the effects of different radiation qualities on normal human breast cells

    As there is a growing number of long-term cancer survivors, the incidence of carcinogenesis as a late effect of radiotherapy is getting more and more into the focus. The risk for the development of secondary m...

    Dajana Juerß, Monique Zwar, Ulrich Giesen, Ralf Nolte, Stephan Kriesen, Giorgio Baiocco, Monika Puchalska, Marc-Jan van Goethem, Katrin Manda and Guido Hildebrandt

    Radiation Oncology 2017 12:159

    Published on: 25 September 2017

  4. Research

    Combined high dose radiation and pazopanib in metastatic renal cell carcinoma: a phase I dose escalation trial

    The primary objective was to determine maximum tolerated radiation dose in patients with metastatic renal cell carcinoma on pazopanib treatment.

    Katrien De Wolf, Sylvie Rottey, Karim Vermaelen, Karel Decaestecker, Nora Sundahl, Lizzy De Lobel, Els Goetghebeur, Gert De Meerleer, Nicolaas Lumen, Valérie Fonteyne, Daan De Maeseneer and Piet Ost

    Radiation Oncology 2017 12:157

    Published on: 22 September 2017

  5. Research

    Comparison of volumetric-modulated arc therapy using simultaneous integrated boosts (SIB-VMAT) of 45 Gy/55 Gy in 25 fractions with conventional radiotherapy in preoperative chemoradiation for rectal cancers: a propensity score case-matched analysis

    The aim of this retrospective study was to compare volumetric-modulated arc therapy using simultaneous integrated boosts (SIB-VMAT) of 45 Gy/55 Gy in 25 fractions with three-dimensional conformal radiotherapy ...

    Hideomi Yamashita, Soichiro Ishihara, Hiroaki Nozawa, Kazushige Kawai, Tomomichi Kiyomatsu, Kae Okuma, Osamu Abe, Toshiaki Watanabe and Keiichi Nakagawa

    Radiation Oncology 2017 12:156

    Published on: 21 September 2017

  6. Review

    Development and clinical application of radiomics in lung cancer

    Since the discovery of X-rays at the end of the 19th century, medical imageology has progressed for 100 years, and medical imaging has become an important auxiliary tool for clinical diagnosis. With the launch of...

    Bojiang Chen, Rui Zhang, Yuncui Gan, Lan Yang and Weimin Li

    Radiation Oncology 2017 12:154

    Published on: 15 September 2017

  7. Research

    Risk for surgical complications after previous stereotactic body radiotherapy of the spine

    Stereotactic body radiotherapy (SBRT) for vertebral metastases has emerged as a promising technique, offering high rates of symptom relief and local control combined with low risk of toxicity. Nonetheless, loc...

    Johannes Roesch, John B.C. Cho, Daniel K. Fahim, Peter C. Gerszten, John C. Flickinger, Inga S. Grills, Maha Jawad, Ronald Kersh, Daniel Letourneau, Frederick Mantel, Arjun Sahgal, John H. Shin, Brian Winey and Matthias Guckenberger

    Radiation Oncology 2017 12:153

    Published on: 11 September 2017

  8. Research

    Comprehensive target geometric errors and margin assessment in stereotactic partial breast irradiation

    Recently developed stereotactic partial breast irradiation (S-PBI) allows delivery of a high biologically potent dose to the target while sparing adjacent critical organs and normal tissue. With S-PBI tumorici...

    Xin Zhen, Bo Zhao, Zhuoyu Wang, Robert Timmerman, Ann Spangler, Nathan Kim, Asal Rahimi and Xuejun Gu

    Radiation Oncology 2017 12:151

    Published on: 11 September 2017

  9. Research

    Stereotactic body radiotherapy for stage I non-small-cell lung cancer using higher doses for larger tumors: results of the second study

    Efficacy of stereotactic body radiotherapy (SBRT) in stage I non–small-cell lung cancer (NSCLC) has almost been established. In Japan, the protocol of 48 Gy in 4 fractions over 4 days has been most often emplo...

    Akifumi Miyakawa, Yuta Shibamoto, Fumiya Baba, Yoshihiko Manabe, Taro Murai, Chikao Sugie, Takeshi Yanagi and Taiki Takaoka

    Radiation Oncology 2017 12:152

    Published on: 11 September 2017

  10. Research

    Long-term patient reported outcomes following radiation therapy for oropharyngeal cancer: cross-sectional assessment of a prospective symptom survey in patients ≥65 years old

    Given the potential for older patients to experience exaggerated toxicity and symptoms, this study was performed to characterize patient reported outcomes in older patients following definitive radiation thera...

    Salman A. Eraj, Mona K. Jomaa, Crosby D. Rock, Abdallah S. R. Mohamed, Blaine D. Smith, Joshua B. Smith, Theodora Browne, Luke C. Cooksey, Bowman Williams, Brandi Temple, Kathryn E. Preston, Jeremy M. Aymar, Neil D. Gross, Randal S. Weber, Amy C. Hessel, Renata Ferrarotto…

    Radiation Oncology 2017 12:150

    Published on: 9 September 2017

  11. Research

    Nadir PSA is a strong predictor of treatment outcome in intermediate and high risk localized prostate cancer patients treated by definitive external beam radiotherapy and androgen deprivation

    The aim of this study is to investigate the effect of tumor characteristics and parameters of treatment response in predicting biochemical disease-free survival (BFS) for patients with intermediate or high ris...

    Fady B. Geara, Muhammad Bulbul, Raja B. Khauli, Therese Y. Andraos, Mirna Abboud, Abdelatif Al Mousa, Nasim Sarhan, Ahmed Salem, Hamza Ghatasheh, Anoud Alnsour, Zeina Ayoub, Ibrahim Abu Gheida, Maya Charafeddine, Mohammed Shahait, Ali Shamseddine, Rami Abu Gheida…

    Radiation Oncology 2017 12:149

    Published on: 7 September 2017

  12. Research

    Local relapse of nasopharyngeal cancer and Voxel-based analysis of FMISO uptake using PET with semiconductor detectors

    Hypoxic cancer cells are thought to be radioresistant and could impact local recurrence after radiotherapy (RT). One of the major hypoxic imaging modalities is [18F]fluoromisonidazole positron emission tomography...

    Yukiko Nishikawa, Koichi Yasuda, Shozo Okamoto, Yoichi M. Ito, Rikiya Onimaru, Tohru Shiga, Kazuhiko Tsuchiya, Shiro Watanabe, Wataru Takeuchi, Yuji Kuge, Hao Peng, Nagara Tamaki and Hiroki Shirato

    Radiation Oncology 2017 12:148

    Published on: 6 September 2017

  13. Research

    Target volume delineation of anal cancer based on magnetic resonance imaging or positron emission tomography

    To compare target volume delineation of anal cancer using positron emission tomography (PET) and magnetic resonance imaging (MRI) with respect to inter-observer and inter-modality variability.

    Espen Rusten, Bernt Louni Rekstad, Christine Undseth, Ghazwan Al-Haidari, Bettina Hanekamp, Eivor Hernes, Taran Paulsen Hellebust, Eirik Malinen and Marianne Grønlie Guren

    Radiation Oncology 2017 12:147

    Published on: 6 September 2017

  14. Research

    Re-irradiation for oligo-recurrence from esophageal cancer with radiotherapy history: a multi-institutional study

    Neoadjuvant chemoradiotherapy following surgery has recently become a standard therapy. The purpose of the present study was to determine the effectiveness and toxicity of re-irradiation for oligo-recurrence i...

    Keiichi Jingu, Yuzuru Niibe, Hideomi Yamashita, Kuniaki Katsui, Toshihiko Matsumoto, Tomohiro Nishina and Atsuro Terahara

    Radiation Oncology 2017 12:146

    Published on: 5 September 2017

  15. Research

    Cone-beam CT reconstruction for non-periodic organ motion using time-ordered chain graph model

    The purpose of this study is to introduce the new concept of a four-dimensional (4D) cone-beam computed tomography (CBCT) reconstruction approach for non-periodic organ motion in cooperation with the time-orde...

    Masahiro Nakano, Akihiro Haga, Jun’ichi Kotoku, Taiki Magome, Yoshitaka Masutani, Shouhei Hanaoka, Satoshi Kida and Keiichi Nakagawa

    Radiation Oncology 2017 12:145

    Published on: 4 September 2017

  16. Research

    Carbon-ion radiotherapy for non-small cell lung cancer with interstitial lung disease: a retrospective analysis

    Lung cancer is frequently complicated by interstitial lung disease (ILD). Treatment protocols for lung cancer patients with ILD have not been established; surgery, chemotherapy, and radiotherapy can all cause ...

    Mio Nakajima, Naoyoshi Yamamoto, Kazuhiko Hayashi, Masataka Karube, Daniel K Ebner, Wataru Takahashi, Makoto Anzai, Kenji Tsushima, Yuji Tada, Koichiro Tatsumi, Tadaaiki Miyamoto, Hiroshi Tsuji, Takehiko Fujisawa and Tadashi Kamada

    Radiation Oncology 2017 12:144

    Published on: 2 September 2017

  17. Research

    Intermediate-term outcome after PSMA-PET guided high-dose radiotherapy of recurrent high-risk prostate cancer patients

    By the use of PSMA positron emission tomography (PET) detection of prostate cancer lesions with a high sensitivity and specificity combined with a favorable lesion to background contrast is feasible. Therefore...

    Sebastian Zschaeck, Peter Wust, Marcus Beck, Waldemar Wlodarczyk, David Kaul, Julian Rogasch, Volker Budach, Christian Furth and Pirus Ghadjar

    Radiation Oncology 2017 12:140

    Published on: 23 August 2017

  18. Research

    Preoperative intensity-modulated radiotherapy with a simultaneous integrated boost combined with Capecitabine in locally advanced rectal cancer: short-term results of a multicentric study

    Preoperative radiotherapy (RT) in combination with fluoropyrimidine-based chemotherapy (CT) is the standard of care in patients with locally advanced, T3-T4 N0–2, rectal cancer (LARC). Given the correlation be...

    Marco Lupattelli, Fabio Matrone, Maria Antonietta Gambacorta, Mattia Osti, Gabriella Macchia, Elisa Palazzari, Luca Nicosia, Federico Navarria, Giuditta Chiloiro, Vincenzo Valentini, Cynthia Aristei and Antonino De Paoli

    Radiation Oncology 2017 12:139

    Published on: 22 August 2017

  19. Research

    The feasibility analysis of omission of elective irradiation to level IB lymph nodes in low-risk nasopharyngeal carcinoma based on the 2013 updated consensus guideline for neck nodal levels

    Level IB metastasis is rare in nasopharyngeal carcinoma (NPC). The purpose of this study is to investigate the high-risk factors for level IB metastasis and evaluate the feasibility of omission of elective irr...

    Xiaomin Ou, Yibing Miao, Xiaoshen Wang, Jianhui Ding, Xiayun He and Chaosu Hu

    Radiation Oncology 2017 12:137

    Published on: 18 August 2017

  20. Study protocol

    Hypo-fractionated SBRT for localized prostate cancer: a German bi-center single treatment group feasibility trial

    For prostate cancer treatment, treatment options with minimal side effects are desired. External beam radiation therapy (EBRT) is non-invasive, standard of care and delivered in either conventional fractionati...

    Ping Jiang, Katja Krockenberger, Reinhard Vonthein, Jane Tereszczuk, Arne Schreiber, Sebastian Liebau, Stefan Huttenlocher, Detlef Imhoff, Panagiotis Balermpas, Christian Keller, Kathrin Dellas, Rene Baumann, Claus Rödel, Guido Hildebrandt, Klaus-Peter Jünemann, Alex S. Merseburger…

    Radiation Oncology 2017 12:138

    Published on: 18 August 2017

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